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Nicotine Addiction
Pathophysiology of Tobacco Dependence


An Article By 
Jack E. Henningfield, Leslie M. Schuh, and Murray E. Jarvik
<Go To The Original Website>

GORSKI-CENAPS Web Publications
Published On: <DATE>          Updated On: August 07, 2001
© Terence T. Gorski, 2001

Training & Consultation:,,  Gorski-CENAPS, 17900 Dixie Hwy, Homewood, IL 60430, 708-799-5000 

Pathophysiology of Tobacco Dependence

J. E. Henningfield and L. M. Schuh
Clinical Pharmacology Branch
National Institute on Drug Abuse
Intramural Research Program
Baltimore, Maryland 21224

M. E. Jarvik
Psychopharmacology Unit
Veterans Affairs Medical Center
Los Angeles, California 90024.

1.    American Psychiatric Association. Diagnostic and statistical manual of mental disorders, 3rd ed. (revised). Washington, DC: American Psychiatric Association, 1987.

2.    Ball JC, Ross A. The effectiveness of methadone maintenance therapy. New York: Springer-Verlag, 1991.

3.    Becker DM, Windsor R, Ockene JK, Berman B, Best JA. Setting the policy, education, and research agenda to reduce tobacco use. Circulation 1994;88:1381-1386.

4.    Benowitz NL. Pharmacokinetics considerations in understanding nicotine dependence. In: The biology of nicotine dependence 1990. Ciba Foundation Symposium 152. Chichester: Wiley, 1990;186-209.

5.    Benowitz NL, Hall SM, Modin G. Persistent increase in caffeine concentrations in people who stop smoking. Br Med J 1989;298:1075-1076.

6.    Benowitz NL, Jacob P, Denaro C, Jenkins R. Stable isotope studies of nicotine kinetics and bioavailability. Clin Pharmacol Ther 1991;49:270-277.

7.    Benwell MM, Balfour DJ, Anderson JM. Evidence that tobacco smoking increases the density of (-)-[3H] nicotine binding sites in human brain. J Neurochem 1988;50:1243-1247.

8.    Breslau N, Fenn N, Peterson EL. Early smoking initiation and nicotine dependence in a cohort of young adults. Drug Alcohol Depend 1994; in press.

9.    Breslau N, Kilbey M, Andreski P. Nicotine dependence, major depression, and anxiety in young adults. Arch Gen Psychiatry 1991;48:1069-1074.

10.  Corrigall WA. Regulation of intravenous nicotine self-administration—dopamine mechanisms. In: Adlkofer F, Thurau K, eds. Effects of nicotine on biological systems. Advances in pharmacological sciences. Boston: Berkhauser Verlag, 1991;423-432.

11.  Domino EF, von Baumgarten AM. Tobacco cigarette smoking and patellar reflex depression. Clin Pharmacol Ther 1969;10:72-78.

12.  Eisen SA, Lyons MJ, Goldberg J, True WR. The impact of cigarette and alcohol consumption on weight and obesity: an analysis of 1911 monozygotic male twin pairs. Arch Intern Med 1993;153:2457-2463.

13.  Evans S, Cone E, Marco AP, Henningfield JE. A comparison of the arterial kinetics of smoked and intravenous cocaine. In: Harris L, ed. Problems of drug dependence 1992. NIDA research monograph. Washington DC: US Government Printing Office, NIH publication no. 93-3505, 1993;343.

14.  Fagerström KO, Hurt RD, Säwe U, Tönnesen P. Therapeutic use of nicotine patches: efficacy and safety. J Smoking-Related Dis 1992;3:247-261.

15.  Fagerström KO, Schneider NG, Lunell E. Effectiveness of nicotine patch and nicotine gum as individual versus combined treatments for tobacco withdrawal symptoms. Psychopharmacology 1993;111:271-277.

16.  Ferno O. The development of chewing gum containing nicotine and some comments on the role played by nicotine in the smoking habit. In: Steinfeld J, Griffiths W, Ball K, Taylor RM, eds. Smoking and health. Proceedings of the 3rd world congress on smoking and health. Washington, DC: US Government Printing Office, DHEW publication no. (NIH) 77-1413, 1977;569-573.

17.  Fiore MC. Trends in cigarette smoking in the United States. The epidemiology of tobacco use. Med Clin North Am 1992;76:289-303.

18.  Fiore MC, Jorenby DE, Baker TB, Kenford SL. Tobacco dependence and the nicotine patch. JAMA 1992;268:1-9.

19.  Foulds J. Does nicotine replacement therapy work? [editorial] Addiction 1993;88:1473-1478.

20.  Foulds J, Stapleton J, Hayward M, Russell MAH, Feyerabend C, Fleming T, Costello J. Transdermal nicotine patches with low-intensity support to aid smoking cessation in outpatients in a general hospital. Arch Fam Med 1993;2:417-423.

21.  George H. Gallup International Institute. Teen-age attitudes and behavior concerning tobacco. Report of the findings. Princeton, NJ, September 1992.

22.  Glassman AH, Stetner F, Walsh T, Raizman PS, Fleiss JL, Cooper TB, Covey LS. Heavy smokers, smoking cessation, and clonidine. JAMA 1988;259:2863-2866.

23.  Goldberg SR, Risner ME, Stolerman IP, Reavill C, Garcha HS. Nicotine and some related compounds: effects on schedule-controlled behavior and discriminative properties in rats. Psychopharmacology 1989;97:295-302.

24.  Gross J, Stitzer ML. Nicotine replacement: ten-week effects on tobacco withdrawal symptoms. Psychopharmacology 1989;98: 334-341.

25.  Hatsukami D, Lando H. Behavioral treatment for smoking cessation. Health Values 1993;17:32-40.

26.  Heishman SJ, Snyder FR, Henningfield JE. Performance, subjective, and physiological effects of nicotine in nonsmokers. Drug Alcohol Depend 1993;34:11-18.

27.  Henningfield JE. Occasional drug use: comparing nicotine with other addictive drugs. Tobacco Control 1992;1:161-162.

28.  Henningfield JE, Clayton R, Pollin W. The involvement of tobacco in alcoholism and illicit drug use. Br J Addict 1990;85:279-292.

29.  Henningfield JE, Cohen C, Slade JD. Is nicotine more addictive than cocaine? Br J Addict 1991;86:565-569.

30.  Henningfield JE, Goldberg SR. Nicotine as a reinforcer in human subjects and laboratory animals. Pharmacol Biochem Behav 1983;19:989-992.

31.  Henningfield JE, Keenan RM. Nicotine delivery kinetics and abuse liability. J Consult Clin Psychol 1993;61:1-8.

32.  Henningfield JE, Radzius A, Cooper TM, Clayton RR. Drinking coffee and carbonated beverages blocks absorption of nicotine from nicotine polacrilex gum. JAMA 1990;264:1560-1564.

33.  Henningfield JE, Stapleton JM, Benowitz NL, Grayson RF, London ED. Higher levels of nicotine in arterial than in venous blood after cigarette smoking. Drug Alcohol Depend 1993;33:23-29.

34.  Hughes JR, Gulliver SB, Fenwick JW, Valliere WA, Cruser K, Pepper S, Shea P, Solomon LJ, Flynn BS. Smoking cessation among self-quitters. Health Psychol 1992;11:331-334.

35.  Hughes JR, Gust SW, Keenan R, et al. Long-term use of nicotine vs placebo gum. Arch Intern Med 1991;151:1993-1998.

36.  Hughes JR, Gust SW, Keenan M, Fenwick JW, Healey ML. Nicotine vs placebo gum in general medical practice. JAMA 1989; 261:1300-1305.

37.  Hughes JR, Hatsukami DK. The nicotine withdrawal syndrome: a brief review and update. Int J Smoking Cessation 1992;1:21-26.

38.  Jaffe JH, Jarvik ME. Tobacco use and tobacco use disorder. In: Lipton MA, DiMascio A, Killam KF, eds. Psychopharmacology: a generation of progress. New York: Raven Press, 1978;1665-1676.

39.  Jarvik ME. Beneficial effects of nicotine. Br J Addict 1991;86:571-575.

40.  Jarvik ME, Henningfield JE. Pharmacological adjuncts for the treatment of nicotine dependence. In: Slade JD, Orleans CT, eds. Nicotine addiction: principles and management. New York: Oxford University Press, 1993.

41.  Johnston LM. Tobacco smoking and nicotine. Lancet 1942;2:742.

42.  Jones RT. Tobacco dependence. In: Meltzer HY, ed. Psychopharmacology: the third generation of progress. New York: Raven Press, 1987.

43.  Keenan RM, Hatsukami DK, Pentel PR, Thompson T, Grillo MA. Pharmacodynamic effects of cotinine in abstinent smokers. Clin Pharmacol Ther 1994;55:581-590.

44.  Kellam SG, Ensminger ME, Simon MB. Mental health in first grade and teenage drug, alcohol, and cigarette use. Drug Alcohol Depend 1980;5:273-304.

45.  Kendler KS, Neale MC, MacLean CJ, et al. Smoking and major depression. A causal analysis. Arch Gen Psychiatry 1993;50:36-43.

46.  Klesges RC, Meyers AW, Klesges LM, LaVasque ME. Smoking, body weight, and their effects on smoking behavior: a comprehensive review of the literature. Psychol Bull 1989;106:204-230.

47.  Lee BL, Benowitz NL, Jacob P. Cigarette abstinence, nicotine gum, and theophylline disposition. Ann Intern Med 1987;106:553-555.

48.  Leischow SJ, Valente SN, Hill AL, Otte PS, Aickin M, Kligman EW. Nicotine patch and gum: withdrawal symptoms, side effects, and medication preference. In: Harris L, ed. Problems of drug dependence 1993. NIDA research monograph. Washington, DC: US Government Printing Office, 1994;(in press).

49.  London ED, Morgan MJ. Positron emission tomographic studies on the acute effects of psychoactive drugs on brain metabolism and mood. In: London ED, ed. Imaging drug action in the brain. Boca Raton, FL: CRC Press, 1993:265-280.

50.  Luchessi BR, Schuster CR, Emley AB. The role of nicotine as a determinant of cigarette smoking frequency in man with observations of certain cardiovascular effects associated with the tobacco alkaloid. Clin Pharmacol Ther 1967:789-796.

51.  McGinnis JM, Foege WH. Actual causes of death in the United States. JAMA 1993;270:2207-2212.

52.  McNeill AD. The development of dependence on smoking in children. Br J Addict 1991;86:589-592.

53.  Newhouse PA, Hughes JR. The role of nicotine and nicotinic mechanisms in neuropsychiatric disease. Br J Addict 1991;86:521-526.

54.  Pickworth WB, Bunker EB, Henningfield JE. Transdermal nicotine: Reduction of smoking with minimum abuse liability. Psychopharmacology 1994; in press.

55.  Pickworth WB, Herning RI, Henningfield JE. Spontaneous EEG changes during tobacco abstinence and nicotine substitution. J Pharmacol Exp Ther 1989;251:976-982.

56.  Pomerleau OF. Nicotine and the central nervous system: Biobehavioral effects of cigarette smoking. Am J Med 1992;93(suppl 1A):2A-7S.

57.  Pomerleau OF, Pomerleau CS. Neuroregulators and the reinforcement of smoking: towards a biobehavioral explanation. Neurosci Biobehav Rev 1984;8:503-513.

58.  Pomerleau OF, Rosecrans J. Neuroregulatory effects of nicotine. Psychoneuroendocrinology 1989;14:407-423.

59.  Raveis VH, Kandel DB. Changes in drug behavior from middle to late 20s: initiation, persistence and cessation of use. Am J Public Health 1987;77:607-611.

60.  Rose JE, Jarvik ME, Rose KD. Transdermal administration of nicotine. Drug Alcohol Depend 1984;13:209-213.

61. Ross HD, Chan KH, Piraino AJ, John VA. Pharmacokinetics of multiple daily transdermal doses of nicotine in healthy smokers. Pharmacol Res 1991;8:385-388.

62.  Russell MAH. The nicotine addiction trap: a 40-year sentence for four cigarettes. Br J Addiction 1990;85:295-300.

63.  Sachs DPL. Advances in smoking cessation treatment. Curr Pulmonol 1991;12:139-198.

64.  Sachs DPL, Leischow SJ. Pharmacologic approaches to smoking cessation. Clin Chest Med 1991;12:769-791.

65.  Sahakian B, Jones G, Levy R, Gray J, Warburton D. The effects of nicotine on attention, information processing, and short-term memory in patients with dementia of the Alzheimer's type. Br J Psychiatry 1989;154:797-800.

66.  Sanberg PR, Fogelson HM, Mandersheid PZ, Parker KW, Norman AB, McConville BJ. Nicotine gum and haloperidol in Tourette's syndrome. Lancet 1988;1:592.

67.  Sheiner LB. Clinical pharmacology and the choice between theory and empiricism. Clin Pharmacol Ther 1989;46:605-615.

68.  Silverman K, Evans SM, Strain EC, Griffiths RR. Withdrawal syndrome after the double-blind cessation of caffeine consumption. N Engl J Med 1992;327:1109-1114.

69.  Slade J. Nicotine addiction. Blakeman EM, Engelberg AL, eds. Tobacco use in America conference. Washington, DC: American Medical Association, 1991;7-11.

70.  Srivastava ED, Russell MAH, Feyerabend C, Williams GT, Masterson JG, Rhodes J. Transdermal nicotine in active ulcerative colitis. Eur J Gastroenterol Hepatol 1991;3:815-818.

71.  Srivastava ED, Russell MAH, Feyerabend C, Masterson JG, Rhodes J. Sensitivity and tolerance to nicotine in smokers and nonsmokers. Psychopharmacology 1991;105:63-68.

72.  Svensson CK. Clinical pharmacokinetics of nicotine. Clin Pharmacokinet 1987;12:30-40.

73.  Thompson TI, Schuster CR. Behavioral pharmacology. Englewood Cliffs, NJ: Prentice-Hall, 1968.

74.  United States Department of Health and Human Services (US DHHS), Public Health Service. The health consequences of smoking: nicotine addiction: a report of the Surgeon General. Washington, DC: US Government Printing Office, DHHS publication no. (CDC) 88-8406, 1988.

75.  United States Department of Health and Human Services (US DHHS), Public Health Services. Drug abuse and drug abuse research. The Second Triennial Report to Congress from the Secretary, Department of Health and Human Services. Washington, DC: US Government Printing Office, DHHS publication no. (ADM) 87-1486, 1987.

76.  United States Department of Health and Human Services (US DHHS), Public Health Service. The health benefits of smoking cessation: a report of the Surgeon General. Washington, DC: US Government Printing Office, DHHS publication no. (CDC) 90-8416, 1990.

77.  Warburton DM. Nicotine: an addictive substance or a therapeutic agent? Prog Drug Res 1989;33:9-41.

78.  West RJ, Russell MAH, Jarvis MJ, Feyerabend C. Does switching to an ultra-low nicotine cigarette induce nicotine withdrawal effects? Psychopharmacology 1984;84:120-123.

Terry Gorski and other member of the GORSKI-CENAPS Team are Available To Train & Consult On Areas Related To Recovery & Relapse Prevention
Gorski - CENAPS, 17900 Dixie Hwy, Homewood, IL 60430, 708-799-5000,,


Home - What's New - Site Map - Search Gorski's Site - Articles - Book Reviews

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GORSKI-CENAPS Clinical Model --- Research-Based Best Practice Principles

Special Focus:  Mental Health, Substance Abuse, & Terrorism

Terry Gorski and Other Members of the GORSKI-CENAPS Team are Available To Train & Consult On Areas Related To Recovery, Relapse Prevention, & Relapse Early Intervention

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