Addiction: A chronic, relapsing disease characterized by
compulsive drug-seeking and abuse and by long-lasting chemical changes
in the brain.
Cannabinoids: Chemicals that help control mental and physical
processes when produced naturally by the body and that produce
intoxication and other effects when absorbed from marijuana.
Carcinogen: Any substance that causes cancer.
Dopamine: A brain chemical, classified as a neurotransmitter,
found in regions of the brain that regulate movement, emotion,
motivation, and pleasure.
Hippocampus: An area of the brain crucial for learning and
Hydrocarbon: Any chemical compound containing only hydrogen
Psychoactive: Having a specific effect on the mind.
THC: Delta-9-tetrahydrocannabinol; the main active ingredient
in marijuana, which acts on the brain to produce its effects.
Withdrawal: Symptoms that occur after use of a drug is reduced
Adams, I.B., and Martin, B.R. Cannabis: Pharmacology and toxicology
in animals and humans. Addiction 91:1585-1614, 1996.
Block, R.I., and Ghoneim, M.M. Effects of chronic marijuana use on
human cognition. Psychopharmacology 100(1-2):219-228, 1993.
Brook, J.S.; Balka, E.B.; and Whiteman, M. The risks for late
adolescence of early adolescent marijuana use. American Journal of
Public Health 89(10):1549-1554, 1999.
Budney, A.J.; Higgins, S.T.; Radonovich, K.J.; and Novy, P.L. Adding
voucher-based incentives to coping skills and motivational enhancement
improves outcomes during treatment for marijuana dependence. Journal
of Consulting and Clinical Psychology 8(6):1051-1061, 2000.
Cimbura, G.; Lucas, D.M.; Bennett, R.C.; and Donelson, A.C. Incidence
and toxicological aspects of cannabis and ethanol detected in 1394
fatally injured drivers and pedestrians in Ontario (1982-1984). Journal
of Forensic Science 35(5):1035-1041, 1990.
Cimbura, G.; Lucas, D.M.; Bennett, R.C.; Warren, R.A.; and Simpson,
H.M. Incidence and toxicological aspects of cannabis and ethanol
detected in 484 fatally injured drivers and pedestrians in Ontario. Journal
of Forensic Science 27(4):855-867, 1982.
Chan, G.C.K.; Hinds, T.R.; Impey, S.; and Storm, D.R. Hippocampal
neurotoxicity of Δ-9-tetrahydrocannabinol. Journal of
Neuroscience 18(14)5322-5332, 1998.
ElSohly, M.A.; Ross, S.A.; Mehmedic, Z.; Arafat, R.; Yi, B.; and
Banahan, B. Potency trends of delta-9-THC and other cannabinoids in
confiscated marijuana from 1980-1997. Journal of Forensic Sciences
Ford, D.E.; Vu, H.T.; and Anthony, J.C. Marijuana use and cessation
of tobacco smoking in adults from a community sample. Drug and
Alcohol Dependence 67:243-248, 2002.
Fried, P.A. Prenatal exposure to marijuana and tobacco during
infancy, early and middle childhood: Effects and an attempt at
synthesis. Archives of Toxicology Supplement 17:233-260, 1995.
Green, B.E., and Ritter, C. Marijuana use and depression. Journal
of Health and Social Behavior 41(1):40-49, 2000.
Haley, N.R.; Iwuc, P.S.; Ogilvie, L.M.; and Carria, L.R. Motor
vehicle fatalities in Rhode Island (FY 1990-1991): A report on driver
impairment. R I Med 75(8):397-400, 1992.
Haney, M.; Ward, A.S.; Comer, S.D.; Foltin, R.W.; and Fischman, M.W.
Abstinence symptoms following smoked marijuana in humans. Psychopharmacology
Heishman, S.J.; Arasteh, K.; and Stitzer, M.L. Comparative effects of
alcohol and marijuana on mood, memory, and performance. Pharmacology
Biochemistry and Behavior 58:97-101, 1997.
Johnston, L.D.; O'Malley, P.M.; and Bachman, J.G. Monitoring the
Future: National Survey Results on Drug Use, 1975-2001. Volume I:
Secondary School Students. NIH Pub. No. 02-5106. Bethesda, MD: NIDA,
NIH, DHHS, 2002.
Lynskey, M., and Hall, W. The effects of adolescent cannabis use on
educational attainment: A review. Addiction 95(11):1621-1630,
Mason, A.P., and McBay, A.J. Ethanol, marijuana, and other drug use
in 600 drivers killed in single-vehicle crashes in North Carolina,
1978-1981. Journal of Forensic Science 29(4):987-1026, 1984.
National Highway Traffic Safety Administration (NHTSA) Notes.
Marijuana and alcohol combined severely impede driving performance. Annals
of Emergency Medicine 35(4):398-399, 2000.
Office of Applied Studies. Emergency Department Trends From the
Drug Abuse Warning Network, Final Estimates 1994-2001. DAWN Series
D-21. DHHS Pub. No. (SMA) 02-3635. Rockville, MD: SAMHSA, 2002.
Office of Applied Studies. Results from the 2001 National
Household Survey on Drug Abuse: Volume II. Technical Appendices and
Selected Data Tables. NHSDA Series H-18. DHHS Pub. No. (SMA)
02-3759. Rockville, MD: SAMHSA, 2002.
Pope, H.G.; Gruber, A.J.; Hudson, J.I.; Huestis, M.A.; and Yurgelun-Todd,
D. Neuropsychological performance in long-term cannabis users. Archives
of General Psychiatry 58(10):909-915, 2001.
Pope, H.G., and Yurgelun-Todd, D. The residual cognitive effects of
heavy marijuana use in college students. Journal of the American
Medical Association 272(7):521-527, 1996.
Stephens, R.S.; Roffman, R.A.; and Curtin, L. Comparison of extended
versus brief treatments for marijuana use. Journal of Consulting and
Clinical Psychology 68(5):898-908, 2000.
Tashkin, D.P. Pulmonary complications of smoked substance abuse. Western
Journal of Medicine 152:525-530, 1990.