Abstract
From Archive
of General Psychiatry
Preventing
Recurrent Depression Using Cognitive Therapy With and Without a
Continuation Phase
A Randomized Clinical Trial
Robin
B. Jarrett, PhD; Dolores Kraft, PhD; Jeanette Doyle, MA; Barbara M.
Foster, PhD; G. Greg Eaves, PhD; Paul C. Silver, PhD
Background Cognitive therapy (CT) may reduce
depressive relapse and recurrence when patients learn and use the
associated skills. Reported relapse and recurrence rates after CT
discontinuation vary widely. The factors that determine when CT is
preventive remain unidentified. We developed continuation-phase CT
(C-CT) to teach responders skills to prevent relapse. This is the first
randomized trial comparing CT with and without a continuation phase in
responders to CT who were vulnerable, given their history of recurrent
unipolar depression.
Methods Patients aged 18 to 65 years (n = 156) with
recurrent DSM-IV major depressive disorder (MDD) entered 20
sessions of acute-phase CT (A-CT). Unmedicated responders (ie, no MDD
and 17-item Hamilton Rating Scale for Depression score
9;
n = 84) were randomized to either 8 months (10 sessions) of C-CT or
control (evaluation without CT). Follow-up lasted an additional 16
months. A clinician blind to assignment evaluated relapse and recurrence
(ie, DSM-IV MDD).
Results Over an 8-month period, C-CT significantly
reduced relapse estimates more than control (10% vs 31%). Over 24
months, including the CT-free follow-up, age of onset and quality of
remission during the late phase of A-CT each interacted with condition
assignment to influence durability of effects. In patients with
early-onset MDD, C-CT significantly reduced relapse and recurrence
estimates (16% vs 67% in control). When patients had unstable remission
during late A-CT, C-CT significantly reduced relapse and recurrence
estimates to 37% (vs 62% in control).
Conclusions Findings suggest that 8 months of C-CT
significantly reduces relapse and recurrence in the highest-risk
patients with recurrent MDD. Risk factors influenced the necessity for
C-CT.
Arch Gen Psychiatry. 2001;58:381-388